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McCarrey, John R.
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overview Research in Dr. McCarrey’s lab is centered on mammalian germ cells and stem cells. Experimental models include the mouse, the baboon, and the opossum. The lab is interested in the epigenetic regulation of cell functions, including determination of cell fates, maintenance of genetic integrity, regulation of gene expression, genomic imprinting, X-chromosome inactivation and meiotic sex chromosome inactivation, methods of assisted reproduction, the evolution of tissue-specific gene expression in mammalian species, and developing the baboon as a model system for testing stem cell-based therapeutic applications.
One or more keywords matched the following items that are connected to McCarrey, John R.
Item TypeName
Academic Article Primary epimutations introduced during intracytoplasmic sperm injection (ICSI) are corrected by germline-specific epigenetic reprogramming.
Academic Article Dynamic expression pattern and subcellular localization of the Rhox10 homeobox transcription factor during early germ cell development.
Academic Article Enhanced genetic integrity in mouse germ cells.
Academic Article Mechanisms of genetic sex determination, gonadal sex differentiation, and germ-cell development in animals.
Academic Article A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis.
Academic Article Chick gonad differentiation following excision of primordial germ cells.
Academic Article The epigenome as a target for heritable environmental disruptions of cellular function.
Academic Article Expression of Xist in mouse germ cells correlates with X-chromosome inactivation.
Academic Article A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice.
Academic Article Toward a more precise and informative nomenclature describing fetal and neonatal male germ cells in rodents.
Academic Article Environmentally induced transgenerational epigenetic reprogramming of primordial germ cells and the subsequent germ line.
Academic Article Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line.
Academic Article Distinctions between transgenerational and non-transgenerational epimutations.
Academic Article A novel class of somatic small RNAs similar to germ cell pachytene PIWI-interacting small RNAs.
Academic Article Analysis of germ line development in the chick embryo using an anti-mouse EC cell antibody.
Academic Article Isolation of viable mouse primordial germ cells by antibody-directed flow sorting.
Academic Article Parallel evolution of male germline epigenetic poising and somatic development in animals.
Academic Article Functional differentiation of chick gonads following depletion of primordial germ cells.
Academic Article Differential gene expression in fetal mouse germ cells.
Academic Article Transgenerational sperm DNA methylation epimutation developmental origins following ancestral vinclozolin exposure.
Academic Article Mutation frequency declines during spermatogenesis in young mice but increases in old mice.
Academic Article Asynchronous replication of imprinted genes is established in the gametes and maintained during development.
Academic Article Mixed spermatogenic germ cell nuclear extracts exhibit high base excision repair activity.
Academic Article Germline genomes--a biological fountain of youth?
Academic Article Reprogramming of primordial germ cells begins before migration into the genital ridge, making these cells inadequate donors for reproductive cloning.
Academic Article Mutation spectral changes in spermatogenic cells obtained from old mice.
Academic Article The H19 methylation imprint is erased and re-established differentially on the parental alleles during male germ cell development.
Academic Article Base excision repair is limited by different proteins in male germ cell nuclear extracts prepared from young and old mice.
Academic Article Identification, characterization, and functional analysis of sp1 transcript variants expressed in germ cells during mouse spermatogenesis.
Academic Article Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse.
Academic Article SP1 transcription factors in male germ cell development and differentiation.
Academic Article Adult mice cloned from migrating primordial germ cells.
Academic Article Autonomous regulation of sex-specific developmental programming in mouse fetal germ cells.
Academic Article Dynamic nuclear organization of constitutive heterochromatin during fetal male germ cell development in mice.
Academic Article Maintenance of genetic integrity during natural and assisted reproduction.
Academic Article Sex chromosome silencing in the marsupial male germ line.
Academic Article A cytoplasmic variant of the KH-type splicing regulatory protein serves as a decay-promoting factor for phosphoglycerate kinase 2 mRNA in murine male germ cells.
Concept Germ Cells
Concept Germ-Line Mutation
Academic Article Germ cells: ENCODE's forgotten cell type?.
Academic Article Efficient generation of marmoset primordial germ cell-like cells using induced pluripotent stem cells.
Academic Article Developmental alterations in DNA methylation during gametogenesis from primordial germ cells to sperm.
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  • Germ Cells
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